Recombinant MLL2-SET protein

　　原价：￥3,304.60

　　现价：￥2,379.31

　　品牌：Active Motif

　　货号：31420

　　销量：146

　　配送：由沃鎏波洱发货，并提供售后服务

　　规格：50 ug

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　　概述货号31420

　　使用方法Recombinant MLL2-SET is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.

　　性能供应商Active Motif

　　背景MLL2-SET (Myeloid/lymphoid or mixed-lineage leukemia 2) is a Trithorax-group protein that function collectively to promote gene expression. MLL2 is a histone methyltransferase that methylates the Lysine 4 position of histone H3. In particular, the SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. The SET domain is responsible for its histone methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. H3K4 methylation represents a specific epigenetic tag for transcriptional activation. MLL2 is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the β-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome.

　　存放说明Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

　　外观Recombinant MLL2-SET protein was expressed in E. coli cells at a concentration of 0.4 μg/μl in 25 mM Tris pH 8.0, 300 mM NaCl, 5% glycerol, 0.04% Triton X-100.