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Recombinant MLL2-SET protein
原价:¥3,304.60
现价:¥2,379.31
品牌:Active Motif
货号:31420
销量:146
配送:由沃鎏波洱发货,并提供售后服务
规格:50 ug
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概述货号31420
使用方法Recombinant MLL2-SET is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
性能供应商Active Motif
背景MLL2-SET (Myeloid/lymphoid or mixed-lineage leukemia 2) is a Trithorax-group protein that function collectively to promote gene expression. MLL2 is a histone methyltransferase that methylates the Lysine 4 position of histone H3. In particular, the SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. The SET domain is responsible for its histone methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. H3K4 methylation represents a specific epigenetic tag for transcriptional activation. MLL2 is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the β-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome.
存放说明Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
外观Recombinant MLL2-SET protein was expressed in E. coli cells at a concentration of 0.4 μg/μl in 25 mM Tris pH 8.0, 300 mM NaCl, 5% glycerol, 0.04% Triton X-100.