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Recombinant HDAC4 protein
添加时间:2019-11-15

  Recombinant HDAC4 protein

  原价:¥6,277.50

  现价:¥4,519.80

  品牌:Active Motif

  货号:31364

  销量:149

  配送:由沃鎏波洱发货,并提供售后服务

  规格:100 ug

Recombinant HDAC4 protein

  沃鎏波洱(www.valubio.com)致力于打造亚太地区最大的、生命医学科研领域的、集进口科研试剂、耗材、仪器设备销售,品牌推广、技术服务等为一体的一站式电子商务平台,为生命医学提供专业、高效、优质服务。

  沃鎏波洱平台主营生命医学及生物科技相关的产品销售、技术服务等业务,现有600+个品牌,580万+种商品;产品覆盖免疫学、细胞生物学、分子生物学、蛋白质组学等诸多热点学科领域。沃鎏波洱平台将资源和服务进行有效整合,具备了强大的市场获取能力,凭借独特的业务模式获得资本市场青睐。

  概述货号31364

  使用方法Recombinant HDAC4 is suitable for use in histone deacetylase (HDAC) assays. A good starting point is 2 to 5 ng of enzyme per assay.

  性能供应商Active Motif

  背景HDAC4 (Histone Deacetylase 4) is a member of the class IIa mammalian histone deacetylases (HDACs)involved in regulating chromatin structure during transcription. These enzymes catalyze the removal of acetyl groups from lysine residues of histones and other cellular proteins. Lysine N-ε-acetylation is a dynamic, reversible and tightly regulated protein and histone modification that plays a major role in regulation of gene expression in various cellular functions. It consists of the transfer of an acetyl moiety from an acetyl coenzyme A to the ε-amino group of a lysine residue.

  In vivo, acetylation is controlled by the antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). The HDACs are grouped into four classes, on the basis of similarity to yeast counterparts: HDAC class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC6, HDAC7, HDAC9 and 10), class III (SIRT1-7) and class IV (HDAC11).

  Unlike other deacetylases, HDAC4 shuttles between the nucleus and cytoplasm and serves as a nuclear co-repressor that regulates bone and muscle development. HDAC4 interacts with the myocyte enhancer factors Mef2a, Mef2c and Mef2d. It also forms part of a multi-protein complex with RbAp48 and HDAC3. HDAC4 is ubiquitous.

  存放说明Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

  外观100 µg of recombinant HDAC4 protein expressed in E. coli at a concentration of 2.86 mg/ml in 25mM HEPES pH7.5, 200mM KCl, 1mM DTT and 50% glycerol.