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Recombinant MLL4-SET protein
添加时间:2019-11-14

  Recombinant MLL4-SET protein

  原价:¥3,304.60

  现价:¥2,379.31

  品牌:Active Motif

  货号:31422

  销量:197

  配送:由沃鎏波洱发货,并提供售后服务

  规格:50 μg

Recombinant MLL4-SET protein

  沃鎏波洱(www.valubio.com)致力于打造亚太地区最大的、生命医学科研领域的、集进口科研试剂、耗材、仪器设备销售,品牌推广、技术服务等为一体的一站式电子商务平台,为生命医学提供专业、高效、优质服务。

  沃鎏波洱平台主营生命医学及生物科技相关的产品销售、技术服务等业务,现有600+个品牌,580万+种商品;产品覆盖免疫学、细胞生物学、分子生物学、蛋白质组学等诸多热点学科领域。沃鎏波洱平台将资源和服务进行有效整合,具备了强大的市场获取能力,凭借独特的业务模式获得资本市场青睐。

  概述货号31422

  使用方法Recombinant MLL4-SET is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.

  性能供应商Active Motif

  背景Myeloid/lymphoid or mixed-lineage leukemia 4 (MLL4) is a Trithorax-group protein that function collectively to promote gene expression. MLL4 is a histone methyltransferase that methylates the Lysine 4 position of histone H3. In particular, the SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. The SET domain is responsible for its histone methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. H3K4 methylation represents a specific epigenetic tag for transcriptional activation. MLL4 plays a central role in β-globin locus transcription regulation by being recruited by Nfe2. MLL4 is also required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation. MLL4 may also be involved in human cancer as its expression has been shown to be upregulated in solid tumor cell lines.

  存放说明Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

  外观20 µg of recombinant MLL4-SET protein expressed in E. coli at a concentration of 0.4 mg/ml in 20 mM Tris-HCl pH 7.4, 150 mM NaCl and 20% glycerol.