CD34 Monoclonal Antibody (581), Biotin

　　原价：￥2,917.00

　　品牌：Invitrogen

　　货号：CD34-581-15

　　销量：174

　　配送：由沃鎏波洱发货，并提供售后服务

　　规格：500 µL

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　　Product Details

　　TESTED APPLICATIONSDILUTION

　　Flow Cytometry (Flow)5 ul for 1x10^6 cells

　　PUBLISHED APPLICATIONS

　　Flow Cytometry (Flow)See 1 publications below

　　Tested Species reactivityHuman

　　Published species reactivityNot Applicable

　　Host / IsotypeMouse / IgG1

　　ClassMonoclonal

　　TypeAntibody

　　Clone581

　　ImmunogenHuman CD34.

　　ConjugateBiotin

　　FormLiquid

　　Concentration0.03 mg/ml

　　Purificationpurified

　　Storage bufferPBS with BSA

　　Contains0.1% sodium azide

　　Storage conditions4° C

　　RRIDAB_2536503

　　Background/Target Information

　　CD34 is a highly glycosylated monomeric 111-115 kDa surface protein, which is present on many stem cell populations. It is a well established stem cell marker, though its expression on human hematopoietic stem cells is reversible. CD34 probably serves as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions.

　　For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

　　References (1)

　　Have you cited this antibody in a publication? Let us know Let us know so we can reference it in this datasheet.

　　Flow (1)

　　The Journal of clinical investigation

　　Antigen CD34+ marrow cells engraft lethally irradiated baboons.

　　"CD34-581-15 was used in flow cytometry to propose that stem cells responsible for hematopoietic reconstitution are CD34+"

　　Authors Berenson RJ,Andrews RG,Bensinger WI,Kalamasz D,Knitter G,Buckner CD,Bernstein ID

　　Species

　　Not Applicable

　　Dilution

　　Not Cited

　　Year 1988

　　Bioinformatics

　　Protein Aliases: CD34; CD34 antigen; Hematopoietic progenitor cell antigen CD34; Mucosialin; RP11-328D5.2

　　Gene Aliases: CD34

　　UniProt ID: (Human) P28906

　　Entrez Gene ID: (Human) 947

　　Function(s)

　　tissue homeostasis

　　endothelial cell proliferation

　　glomerular filtration

　　endothelium development

　　cell-matrix adhesion

　　signal transduction

　　regulation of blood pressure

　　cell proliferation

　　positive regulation of gene expression

　　negative regulation of gene expression

　　single organismal cell-cell adhesion

　　hemopoiesis

　　negative regulation of blood coagulation

　　negative regulation of tumor necrosis factor production

　　positive regulation of interleukin-10 production

　　mesangial cell-matrix adhesion

　　paracrine signaling

　　positive regulation of odontogenesis

　　negative regulation of nitric oxide biosynthetic process

　　positive regulation of angiogenesis

　　cell motility

　　regulation of immune response

　　leukocyte migration

　　transdifferentiation

　　vascular wound healing

　　hematopoietic stem cell proliferation

　　positive regulation of transforming growth factor beta production

　　positive regulation of granulocyte colony-stimulating factor production

　　extracellular exosome assembly

　　glomerular endothelium development

　　stem cell proliferation

　　metanephric glomerular mesangial cell differentiation

　　negative regulation of cellular response to heat

　　negative regulation of cellular response to hypoxia

　　negative regulation of interleukin-2 secretion

　　positive regulation of glial cell-derived neurotrophic factor secretion

　　negative regulation of neuron death

　　positive regulation of vasculogenesis

　　Process(es)

　　transcription factor binding

　　carbohydrate binding

　　sulfate binding

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　　]

　　Documents

　　Manuals

　　L11381 Human CD34 Antigen Monoclonal Antibodies

　　Material safety data sheets (MSDS)

　　CD3458115_MTR-NALT_EN.pdf