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抗体
p57 Kip2 0.1mL
添加时间:2019-10-29

  p57 Kip2 0.1mL

  现价:¥2,303.00

  品牌:Labvision/Neomarkers

  货号:MS-1062-P0

  销量:177

  配送:由沃鎏波洱发货,并提供售后服务

  规格:0.1mL

p57 Kip2 0.1mL

  沃鎏波洱(www.valubio.com)致力于打造亚太地区最大的、生命医学科研领域的、集进口科研试剂、耗材、仪器设备销售,品牌推广、技术服务等为一体的一站式电子商务平台,为生命医学提供专业、高效、优质服务。

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  概述货号MS-1062-P0

  描述p57Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57Kip2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin-like growth factor II (IGF-II) and H19, both of which seem to be implicated in adrenal neoplasms.

  Epitope: Not determined

  Immunogen: Recombinant human p57Kip2 protein

  Cellular Localization: Nuclear

  Recommended for:

  Immunohistochemistry (Formalin/paraffin)

  Western Blotting (Not suitable)

  Immunoprecipitation (Native verified)

  克隆号57P06; same as KP10

  同种亚型IgG2b/κ

  反应种属Human and Mouse. Others not known.

  来源宿主Mouse

  性能供应商Labvision

  免疫原Recombinant human p57Kip2 protein

  浓度200μg/mL

  计算分子量57kDa

  参考文献1. Overall ML, et al. Genes Chromosomes Cancer 1996 17(1):56-59.

  2. Hatada I, et al. Hum Mol Genet 1996 Jun5(6):783-788.