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Human/Mouse Rab7a Affinity Purified Polyclonal Ab (25 UG)
添加时间:2019-10-28

  Human/Mouse Rab7a Affinity Purified Polyclonal Ab (25 UG)

  原价:¥1,334.57

  现价:¥1,000.93

  品牌:R&D Systems

  货号:AF7789-SP

  销量:231

  配送:0由沃鎏波洱发货,并提供售后服务

  规格:25 UG

Human/Mouse Rab7a Affinity Purified Polyclonal Ab (25 UG)

  沃鎏波洱(www.valubio.com)致力于打造亚太地区最大的、生命医学科研领域的、集进口科研试剂、耗材、仪器设备销售,品牌推广、技术服务等为一体的一站式电子商务平台,为生命医学提供专业、高效、优质服务。

  沃鎏波洱平台主营生命医学及生物科技相关的产品销售、技术服务等业务,现有600+个品牌,580万+种商品;产品覆盖免疫学、细胞生物学、分子生物学、蛋白质组学等诸多热点学科领域。沃鎏波洱平台将资源和服务进行有效整合,具备了强大的市场获取能力,凭借独特的业务模式获得资本市场青睐。

  2018年,沃鎏波洱创新推出科研经销小程序研助宝,致力于打造生物医学共享分销平台,助力服务水平和效率的快速提升,始终以正品保障为底线,帮助经销商降本增效,共同繁荣生物医学产业生态

  概述货号AF7789-SP

  别名CMT2B; FLJ20819; member RAS oncogene family; PRO2706; PSN; RAB7; RAB7A, member RAS oncogene family; Ras-associated protein RAB7; ras-related protein Rab-7a

  全称RAs Genes from Brain Protein 7a

  反应种属Human/Mouse

  应用Western Blot(1 µg/mL)

  目标/特异性Detects human and mouse Rab7a in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant human (rh) Rab9a and rhRab9b is observed.

  使用方法Western Blot: 1 µg/mL

  来源Sterile PBS to a final concentration of 0.2 mg/mL.

  产品组分

  性能供应商R&D Systems

  Entrez Gene IDs7879 (Human); 19349 (Mouse); 29448 (Rat)

  纯化方式Antigen Affinity-purified

  免疫原E. coli-derived recombinant human Rab7a

  Thr2-Ser204

  Accession # P51149

  生物活性Human, Mouse

  标记Unconjugated

  溶解方法Sterile PBS to a final concentration of 0.2 mg/mL.

  背景Rab7a (Ras-related protein Rab 7A; also RAB7) is a 22-24 kDa member of the Rab family, Small GTPase superfamily of proteins. It is widely expressed, and found in cells diverse as skeletal muscle, neurons, osteoclasts and macrophages. Rab7a plays a key role in the formation of phagolysosomes. In particular, Rab7a-GTP becomes associated with early phagosomes. The GTP form of Rab7a first recruits RILP, a molecule that interacts with ORPL1 and promotes the formation of a dynactin:dynein complex. This complex now initiates the movement of the phagosome along microtubules, where it fuses with lysosomes and endosomes at select points, creating phagolysosomes. Human Rab7a is 207 amino acids (aa) in length. It contains multiple Rab family and subfamily motifs, and concludes with a C‑terminal CXC prenylation sequence (aa 205-207). There is one utilized phosphorylation site at Tyr183. Full-length human and mouse Rab7a have identical aa sequences. Notably, however, point mutations with single aa changes are noted in both species. By contrast, human Rab7a and Rab7b share less than 50% aa sequence identity, each representing the product of distinct genes.

  存放说明Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

  12 months from date of receipt, -20 to -70 °C as supplied.

  1 month, 2 to 8 °C under sterile conditions after reconstitution.

  6 months, -20 to -70 °C under sterile conditions after reconstitution.

  参考文献Autophagy

  Diabetic Peripheral Neuropathy

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