Human VAMP-5 Affinity Purified Polyclonal Ab (25 UG)

　　原价：￥1,334.57

　　现价：￥1,000.93

　　品牌：R&D Systems

　　货号：AF7366-SP

　　销量：244

　　配送：0由沃鎏波洱发货，并提供售后服务

　　规格：25 UG

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　　概述货号AF7366-SP

　　别名Myobrevin; VAMP-5; vesicle-associated membrane protein 5 (myobrevin); vesicle-associated membrane protein 5

　　全称Vesicle-Associated Membrane Protein 5

　　反应种属Human

　　应用Immunohistochemistry(5-15 µg/mL)

　　目标/特异性Detects human VAMP-5 in direct ELISAs. In direct ELISAs, approximately 5% cross-reactivity with recombinant human (rh) VAMP-7 is observed, and less than 1% cross-reactivity with rhVAMP-1, rhVAMP-2, and rhVAMP-8 is observed.

　　使用方法Immunohistochemistry: 5-15 µg/mL

　　来源Sterile PBS to a final concentration of 0.2 mg/mL.

　　产品组分

　　性能供应商R&D Systems

　　Entrez Gene IDs10791 (Human); 53620 (Mouse); 89818 (Rat)

　　纯化方式Antigen Affinity-purified

　　免疫原E. coli-derived recombinant human VAMP-5

　　Ala2-Cys72

　　Accession # O95183

　　生物活性Human

　　标记Unconjugated

　　溶解方法Sterile PBS to a final concentration of 0.2 mg/mL.

　　背景VAMP-5 (vesicle associated membrane protein 5; also myobrevin) is a member of the synaptobrevin family of proteins. Although its predicted MW is 11 kDa, it runs anomalously at 16 kDa in SDS-Page. VAMP-5 is a type IV transmembrane (TM) protein (i.e.-a type II TM protein whose C-terminus is almost completely transmembrane) that is found in both trans-Golgi and plasma membranes of myotubes (mature skeletal and cardiac muscle cells). While VAMPs are commonly associated with vesicle fusion to t-SNARE in cell membranes, VAMP-5 appears to show no such activity. Human VAMP-5 is 116 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-72) with one vSNARE coiled-coil homology domain, a 21 aa TM segment, and 23 aa C-terminal luminal domain. Over aa 1-72, human VAMP-5 shares 75% aa identity with mouse VAMP-5.

　　存放说明Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

　　12 months from date of receipt, -20 to -70 °C as supplied.

　　1 month, 2 to 8 °C under sterile conditions after reconstitution.

　　6 months, -20 to -70 °C under sterile conditions after reconstitution.

　　参考文献APP Cleavage and Amyloid-beta Degradation

　　ICC / IHC Images: VAMP-5

　　Neuronal Lineage Markers

　　Synaptic SNAREs

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